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two-tailed, nonparametric spearman correlation test  (GraphPad Software Inc)

 
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    GraphPad Software Inc two-tailed, nonparametric spearman correlation test
    Two Tailed, Nonparametric Spearman Correlation Test, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 1 article reviews
    two-tailed, nonparametric spearman correlation test - by Bioz Stars, 2026-03
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    two-tailed, nonparametric spearman correlation test  (GraphPad Software Inc)
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the nonparametric Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.

    Journal: Biomaterials Research

    Article Title: Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo

    doi: 10.34133/bmr.0112

    Figure Lengend Snippet: Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the nonparametric Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.

    Article Snippet: Correlation analysis in Fig. A to C were performed using nonparametric Spearman correlation tests, also using GraphPad Prism 8.0.

    Techniques: Injection, Concentration Assay, Clinical Proteomics, Comparison, Derivative Assay